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KMID : 0371620080230010033
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Journal of Wonkwang Medical Science
2008 Volume.23 No. 1 p.33 ~ p.38
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The effect of donepezil (Aricept®) on cognitive function, activities of daily living, and quality of life in patients with post-stroke dementia
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Lee Sang-Yeol
Chang Hyuk
Song Jae-Eun
Cho Sung-Ok
Ryu Jung-Mi
Lee Mi-Gyung
Cho Jin-Ho
Shin Yong-Il
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Abstract
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Background: This study evaluated the efficacy of administering Donepezil(Aricept^(?)) for improving cognitive function, activities of daily living, and quality of life in patients with post-stroke dementia.
Methods: Patients(n=99; mean age, 69.89 years; 48.5% men) with post-stroke dementia, according to criteria of the DSM-IV and MRI, were treated with donepezil 5mg/day or 10mg/day during 24 weeks. They were examined using Mini-mental Status Examination(MMSE), Chinical Dementia Rating(CDR), Barthel Activities of daily living(B-ADL), Instrumental Activities of daily living(I-ADL), Short Form 36 Health Survey-Korean(SF-36-K), and Geriatric Depression Scale(GDS) at before treatment and 24 weeks after treatment.
Results: The 97 patients completed the trial. At 24 weeks, they showed significant improvement in MMSE(p＜0.001), CDR(p＜0.001), B-ADL(p=0.002), I-ADL(p＜0.001), and SF-36-K(p=0.003) except GDS(p=0.288). Donepezil was well tolerated. There was no withdrawal due to adverse events.
Conclusion: This results demonstrate that donepezil was beneficial in improving the cognitive function, activities of daily living, and quality of life in patients with post-stroke dementia and was well toleraetd.
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KEYWORD
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Donepezil, cognitive function, activities of daily living, quality of life, post-stroke dementia
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